RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling

RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling

Respiratory syncytial virus infection is responsible for seasonal upper and lower respiratory tract infections worldwide, causing substantial morbidity. Self-inoculation of the virus into the nasopharynx results in epithelial replication and distal spread into the lower respiratory tract. Here, resp...

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Bibliographic Details
Main Author: Allan R. Brasier
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
Airway remodeling
cyclin dependent kinase 9 (CDK9)
bromodomain containing protein 4 (BRD4)
mesenchymal transition
myofibroblast
epigenetics
Online Access:https://www.mdpi.com/1999-4915/12/4/472

Internet

https://www.mdpi.com/1999-4915/12/4/472

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