Development of novel arginase inhibitors for therapy of endothelial dysfunction

Development of novel arginase inhibitors for therapy of endothelial dysfunction

Endothelial dysfunction and resulting vascular pathology have been identified as an early hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to endothelial dysfunction is a decrease in nitric oxide (NO) bioavailability, impaired NO signaling and an increase in...

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Bibliographic Details
Main Authors: Jochen eSteppan, Daniel eNyhan, Dan eBerkowitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Arginase
Diabetes Mellitus
Endothelium
Reactive Oxygen Species
endothelial dysfunction
L-arginine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00278/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00278/full

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