GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action

GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action

GDNF is a potent neurotrophic factor for nigrostriatal dopaminergic neurons in vitro and in animal models of Parkinson's disease (PD), but has largely failed when tested in therapeutic applications in human PD. We report here that GDNF requires transforming growth factor-β (TGF-β) to elicit its...

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Bibliographic Details
Main Authors: Andreas Schober, Heike Peterziel, Christopher S. von Bartheld, Horst Simon, Kerstin Krieglstein, Klaus Unsicker
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Neurotrophic factors
Dopaminergic neurons
Cell death
Engrailed-1
Retrograde transport
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002567

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http://www.sciencedirect.com/science/article/pii/S0969996106002567

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