Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Abstract Background Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in...

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Bibliographic Details
Main Authors: Erik Lindström, Biljana Rizoska, Ian Henderson, Ylva Terelius, Markus Jerling, Charlotte Edenius, Urszula Grabowska
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Translational Medicine
Subjects:
Cathepsin K
Osteoarthritis
CTX-I
NTX-I
CTX-II
Subchondral bone
Online Access:http://link.springer.com/article/10.1186/s12967-018-1497-4

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http://link.springer.com/article/10.1186/s12967-018-1497-4

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