Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

Epidermal growth factor receptor (EGFR) is a novel target for therapy in subsets of non-small cell lung cancer, especially adenocarcinoma. Tumors with EGFR mutations showed good response to EGFR tyrosine kinase inhibitors (TKIs). We aimed to identify the discriminating capacity of immunohistochemica...

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Bibliographic Details
Main Authors: Shang-Gin Wu, Yih-Leong Chang, Jou-Wei Lin, Chen-Tu Wu, Hsuan-Yu Chen, Meng-Feng Tsai, Yung-Chie Lee, Chong-Jen Yu, Jin-Yuan Shih
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858063/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858063/?tool=EBI

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