Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II,...

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Bibliographic Details
Main Authors: Allison Sang, Thomas Danhorn, Jacob N. Peterson, Andrew L. Rankin, Brian P. O’Connor, Sonia M. Leach, Raul M. Torres, Roberta Pelanda
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06293-z

Internet

https://doi.org/10.1038/s41467-018-06293-z

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