Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

Abstract The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular docking was conducted in the COX-2 active site to predict the plausible bindin...

Full description

Bibliographic Details
Main Authors: Hatem A. Abuelizz, Rashad Al-Salahi, Jamil Al-Asri, Jérémie Mortier, Mohamed Marzouk, Essam Ezzeldin, Azza A. Ali, Mona G. Khalil, Gerhard Wolber, Hazem A. Ghabbour, Abdulrahman A. Almehizia, Gehad A. Abdel Jaleel
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Chemistry Central Journal
Online Access:http://link.springer.com/article/10.1186/s13065-017-0321-1

Internet

http://link.springer.com/article/10.1186/s13065-017-0321-1

Similar Items