VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae Cells

VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae Cells

vanZ, a member of the VanA glycopeptide resistance gene cluster, confers resistance to lipoglycopeptide antibiotics independent of cell wall precursor modification by the vanHAX genes. Orthologs of vanZ are present in the genomes of many clinically relevant bacteria, including Enterococcus faecium a...

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Bibliographic Details
Main Authors: Vladimir Vimberg, Leona Zieglerová, Karolína Buriánková, Pavel Branny, Gabriela Balíková Novotná
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
Streptococcus pneumoniae
antibiotic resistance
lipoglycopeptide antibiotics
VanZ
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00566/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00566/full

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