Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene

Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene

Combining virus-enhanced immunogenicity with direct delivery of immunomodulatory molecules would represent a novel treatment modality for melanoma, and would require development of new viral vectors capable of targeting melanoma cells preferentially. Here we explore the use of rodent protoparvovirus...

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Bibliographic Details
Main Authors: Matthew Marr, Anthony D’Abramo, Nikea Pittman, Mavis Agbandje-McKenna, Susan F. Cotmore, Peter Tattersall
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Viruses
Subjects:
protoparvovirus
oncotropic
melanoma
targeting
selection
recombination
mutation
enhancement
chimera
structure
Online Access:http://www.mdpi.com/1999-4915/10/2/54

Internet

http://www.mdpi.com/1999-4915/10/2/54

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