Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and ANG II infusion by...

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Bibliographic Details
Main Authors: Raffaele Altara, Romain Harmancey, Sean P Didion, George W. Booz, Fouad Zouein, Fouad A Zouein
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
Hypertension
Mitochondria
cardiac function
cardiac hypertrophy
fatty acid oxidation
metabolism.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00436/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00436/full

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