Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric in...

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Bibliographic Details
Main Authors: Yvonne H. Chan, Sergey V. Venev, Konstantin B. Zeldovich, C. Robert Matthews
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14614