Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D...

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Bibliographic Details
Main Authors: Xiuming Peng, Fumin Liu, Haibo Wu, Xiaorong Peng, Yufan Xu, Liyan Wang, Bin Chen, Tao Sun, Fan Yang, Shujing Ji, Nanping Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
avian influenza virus
H5N6
virulence
adaption
mice
amino acids
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00453/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00453/full

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