GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

Abstract Background Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tumor cell survival and chemoresistance. The aim of...

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Bibliographic Details
Main Authors: Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal, Hervé Sartelet
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
Bcl-2
Neuroblastoma
Apoptosis
Autophagy
GX15–070
Online Access:http://link.springer.com/article/10.1186/s12885-019-6195-y

Internet

http://link.springer.com/article/10.1186/s12885-019-6195-y

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