SNP Discovery Using a Pangenome: Has the Single Reference Approach Become Obsolete?

SNP Discovery Using a Pangenome: Has the Single Reference Approach Become Obsolete?

Increasing evidence suggests that a single individual is insufficient to capture the genetic diversity within a species due to gene presence absence variation. In order to understand the extent to which genomic variation occurs in a species, the construction of its pangenome is necessary. The pangen...

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Bibliographic Details
Main Authors: Bhavna Hurgobin, David Edwards
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Biology
Subjects:
pangenome
single nucleotide polymorphism
SNP discovery
copy number variation
presence absence variation
gene
assembly
genetic diversity
core genome
variable genome
Online Access:http://www.mdpi.com/2079-7737/6/1/21

Internet

http://www.mdpi.com/2079-7737/6/1/21

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