Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes

Enterocyte cholesterol homeostasis reflects aggregated rates of sterol synthesis, efflux, and uptake from plasma and gut lumen. Cholesterol synthesis and LDL uptake are coordinately regulated by sterol regulatory element-binding proteins (SREBP), whereas sterol efflux is regulated by liver X recepto...

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Bibliographic Details
Main Authors: Luke J. Engelking, Matthew R. McFarlane, Christina K. Li, Guosheng Liang
Format: Article
Language:English
Published: Elsevier 2012-07-01
Series:Journal of Lipid Research
Subjects:
cholesterol/absorption
cholesterol/biosynthesis
LDL/metabolism
lipoproteins/receptors
nuclear receptors
HMG-CoA reductase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345120

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http://www.sciencedirect.com/science/article/pii/S0022227520345120

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