Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors

Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors

The 3,3′,5,5′-tetrachloro-2-iodo-4,4′-bipyridine structure is proposed as a novel chemical scaffold for the design of new transthyretin (TTR) fibrillogenesis inhibitors. In the frame of a proof-of-principle exploration, four chiral 3,3′,5,5′-tetrachloro-2-iodo-2′-substituted-4,4′- bipyridines were r...

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Bibliographic Details
Main Authors: Alessandro Dessì, Paola Peluso, Roberto Dallocchio, Robin Weiss, Giuseppina Andreotti, Mariateresa Allocca, Emmanuel Aubert, Patrick Pale, Victor Mamane, Sergio Cossu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
bipyridines
docking
fibril formation
halogen bond
misfolding inhibition
transthyretin
Online Access:https://www.mdpi.com/1420-3049/25/9/2213

Internet

https://www.mdpi.com/1420-3049/25/9/2213

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