Lithium impacts on the amplitude and period of the molecular circadian clockwork.

Lithium salt has been widely used in treatment of Bipolar Disorder, a mental disturbance associated with circadian rhythm disruptions. Lithium mildly but consistently lengthens circadian period of behavioural rhythms in multiple organisms. To systematically address the impacts of lithium on circadia...

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Bibliographic Details
Main Authors: Jian Li, Wei-Qun Lu, Stephen Beesley, Andrew S I Loudon, Qing-Jun Meng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3299767?pdf=render