Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH.

Therapy-related acute leukemia (t-AML), is a severe complication of cytotoxic therapy used for primary cancer treatment. The outcome of these patients is poor, compared to people who develop de novo acute leukemia (p-AML). Cytogenetic abnormalities in t-AML are similar to those found in p-AML but pr...

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Main Authors: Nathalie Itzhar, Philippe Dessen, Saloua Toujani, Nathalie Auger, Claude Preudhomme, Catherine Richon, Vladimir Lazar, Véronique Saada, Anelyse Bennaceur, Jean Henri Bourhis, Stéphane de Botton, Alain Bernheim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21339820/?tool=EBI