Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting ce...

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Bibliographic Details
Main Authors: Jane Ying-Chieh Lee, Ching-Wen eKuo, Shing-Ling eTsai, Siao Muk eCheng, Shang-Hung eChen, Hsiu-Han eChan, Chun-Hui eLin, Kun-Yuan eLin, Chien-Feng eLi, Jagat Rakesh Kanwar, Euphemia Yee Leung, Carlos Chun Ho Cheung, Wei-Jan eHuang, Yi-Ching eWang, Chun Hei Antonio eCheung
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
HDAC
XIAP
survivin
SAHA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00081/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00081/full

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