Hepatic Stellate Cell Activation and Inactivation in NASH‑Fibrosis—Roles as Putative Treatment Targets?

Hepatic fibrosis is the primary predictor of mortality in patients with non-alcoholic steatohepatitis (NASH). In this process, the activated hepatic stellate cells (HSCs) constitute the principal cells responsible for the deposition of a fibrous extracellular matrix, thereby driving the hepatic scar...

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Bibliographic Details
Main Authors: Alexandra Zisser, David H. Ipsen, Pernille Tveden-Nyborg
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/9/4/365