Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Abstract Background Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular communication via transfer of genetic material. However, the miRNAs in...

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Bibliographic Details
Main Authors: Dongdong Jiang, Fangyi Gong, Xuhui Ge, Chengtang Lv, Chenyu Huang, Shuang Feng, Zheng Zhou, Yuluo Rong, Jiaxing Wang, Chengyue Ji, Jian Chen, Wene Zhao, Jin Fan, Wei Liu, Weihua Cai
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Nanobiotechnology
Subjects:
Spinal cord injury
Exosomes
Microglia
Astrocytes
miR-124-3p/MYH9 axis
Online Access:http://link.springer.com/article/10.1186/s12951-020-00665-8

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http://link.springer.com/article/10.1186/s12951-020-00665-8

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