A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8+ T Cells in a Nonalcoholic Steatohepatitis Mouse Model

A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8+ T Cells in a Nonalcoholic Steatohepatitis Mouse Model

Background and AimsThe mineralocorticoid receptor (MR) and renin-angiotensin-aldosterone system (RAAS) are implicated in non-alcoholic liver fatty disease (NALFD). However, inflammatory mechanisms linking MR and RAAS with disease pathology remain unclear. Here we aimed to evaluate the contribution o...

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Bibliographic Details
Main Authors: Natalia Muñoz-Durango, Marco Arrese, Alejandra Hernández, Evelyn Jara, Alexis M. Kalergis, Daniel Cabrera
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
non-alcoholic steatohepatitis
steatohepatitis
fatty liver
inflammation
fibrosis
mineralocorticoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.563434/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.563434/full

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