Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes.

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes.

Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope. However, many of these proteins do not function on Gram-negative bacteria, because the...

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Bibliographic Details
Main Authors: Dani A C Heesterbeek, Remy M Muts, Vincent P van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W Bardoel, Nina M van Sorge, Suzan H M Rooijakkers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009227

Internet

https://doi.org/10.1371/journal.ppat.1009227

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