Pharmacogenetic Study of Trabectedin-Induced Severe Hepatotoxicity in Patients with Advanced Soft Tissue Sarcoma

Pharmacogenetic Study of Trabectedin-Induced Severe Hepatotoxicity in Patients with Advanced Soft Tissue Sarcoma

Hepatotoxicity is an important concern for nearly 40% of the patients treated with trabectedin for advanced soft tissue sarcoma (ASTS). The mechanisms underlying these liver damages have not yet been elucidated but they have been suggested to be related to the production of reactive metabolites. The...

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Bibliographic Details
Main Authors: Maud Maillard, Christine Chevreau, Félicien Le Louedec, Manon Cassou, Caroline Delmas, Laure Gourdain, Jean-Yves Blay, Didier Cupissol, Emmanuelle Bompas, Antoine Italiano, Nicolas Isambert, Corinne Delcambre-Lair, Nicolas Penel, François Bertucci, Cécile Guillemet, Julien Plenecassagnes, Stéphanie Foulon, Étienne Chatelut, Axel Le Cesne, Fabienne Thomas
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
ABC transporters
advanced soft tissue sarcoma
CYP450
hepatotoxicity
next-generation sequencing
pharmacogenetic
Online Access:https://www.mdpi.com/2072-6694/12/12/3647

Internet

https://www.mdpi.com/2072-6694/12/12/3647

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