Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling. Aberrant Notch signaling in T-ALL occurs by NOTCH1 gain-of-function mutations and by NOTCH3 overexpression. Although NOTCH3 is assumed...

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Bibliographic Details
Main Authors: Luca Tottone, Nadezda Zhdanovskaya, Álvaro Carmona Pestaña, Michele Zampieri, Fabrizio Simeoni, Sara Lazzari, Valeria Ruocco, Maria Pelullo, Paola Caiafa, Maria Pia Felli, Saula Checquolo, Diana Bellavia, Claudio Talora, Isabella Screpanti, Rocco Palermo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
Notch signaling
T-cell lymphoblastic leukemia
epigenetics
JMJD3
p300
gene regulation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00198/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00198/full

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