Rapid Identification of Key Copy Number Alterations in B- and T-Cell Acute Lymphoblastic Leukemia by Digital Multiplex Ligation-Dependent Probe Amplification

Rapid Identification of Key Copy Number Alterations in B- and T-Cell Acute Lymphoblastic Leukemia by Digital Multiplex Ligation-Dependent Probe Amplification

Recurrent clonal genetic alterations are the hallmark of Acute Lymphoblastic Leukemia (ALL) and govern the risk stratification, response to treatment and clinical outcome. In this retrospective study conducted on ALL patient samples, the purpose was to estimate the copy number alterations (CNAs) in...

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Bibliographic Details
Main Authors: Deepshi Thakral, Gurvinder Kaur, Ritu Gupta, Anne Benard-Slagter, Suvi Savola, Indresh Kumar, Rajni Anand, Lata Rani, Pramod Verma, Sangeeta Joshi, Lalit Kumar, Atul Sharma, Sameer Bakhshi, Rachna Seth, Vivek Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
copy number alterations
CNAs
B-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia
digital multiplex ligation-dependent probe amplification
dMLPA
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00871/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00871/full

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