The Epithelial-Mesenchymal Transcription Factor Slug Predicts Survival Benefit of Up-Front Surgery in Head and Neck Cancer

The Epithelial-Mesenchymal Transcription Factor Slug Predicts Survival Benefit of Up-Front Surgery in Head and Neck Cancer

EMT promotes radio- and chemotherapy resistance in HNSCC in vitro. As EMT has been correlated to the transcription factor Slug in tumor specimens from HNSCC patients, we assessed whether Slug overexpression predicts radio- and chemotherapy resistance and favors upfront surgery in HNSCC patients. Slu...

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Bibliographic Details
Main Authors: Herbert Riechelmann, Teresa Bernadette Steinbichler, Susanne Sprung, Matthias Santer, Annette Runge, Ute Ganswindt, Gabriele Gamerith, Jozsef Dudas
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
head and neck cancer
epithelial–mesenchymal transition
snail family transcription factors
biomarker
prognosis
proportional hazards models
Online Access:https://www.mdpi.com/2072-6694/13/4/772

Internet

https://www.mdpi.com/2072-6694/13/4/772

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