Is Polymorphism in the Apoptosis and Inflammatory Pathway Genes Associated With a Primary Response to Anti-TNF Therapy in Crohn’s Disease Patients?

Is Polymorphism in the Apoptosis and Inflammatory Pathway Genes Associated With a Primary Response to Anti-TNF Therapy in Crohn’s Disease Patients?

Anti-tumor necrosis factor (TNF) therapy is used for the induction and maintenance of remission in Crohn’s disease (CD) patients. However, primary nonresponders to initial treatment constitute 20%–40% of cases. The causes of this phenomenon are still unknown. In this study, we aimed to determine the...

Full description

Bibliographic Details
Main Authors: Michal Walczak, Liliana Lykowska-Szuber, Marianna Plucinska, Kamila Stawczyk-Eder, Oliwia Zakerska-Banaszak, Piotr Eder, Iwona Krela-Kazmierczak, Michal Michalak, Marek Zywicki, Wojciech M. Karlowski, Marlena Szalata, Agnieszka Dobrowolska, Ryszard Slomski, Marzena Skrzypczak-Zielinska
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
Crohn’s disease
biological therapy
genetics
response
anti-TNF drugs, next-generation sequencing, apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01207/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01207/full

Similar Items