Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Summary: CDK7 phosphorylates the RNA polymerase II (pol II) C-terminal domain CTD and activates the P-TEFb-associated kinase CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog-sensitive (CDK7as) cells, we observed reduced capping enzyme recruitment, increased pol II promote...

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Bibliographic Details
Main Authors: Christopher C. Ebmeier, Benjamin Erickson, Benjamin L. Allen, Mary A. Allen, Hyunmin Kim, Nova Fong, Jeremy R. Jacobsen, Kaiwei Liang, Ali Shilatifard, Robin D. Dowell, William M. Old, David L. Bentley, Dylan J. Taatjes
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309877

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http://www.sciencedirect.com/science/article/pii/S2211124717309877

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