Adenosinergic Signaling Alters Natural Killer Cell Functional Responses

Adenosinergic Signaling Alters Natural Killer Cell Functional Responses

Adenosine is a potent immunosuppressive purine metabolite contributing to the pathogenesis of solid tumors. Extracellular adenosine signals on tumor-infiltrating NK cells to inhibit their proliferation, maturation, and cytotoxic function. Cytokine priming imparts upon NK cells distinct activation st...

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Bibliographic Details
Main Authors: Andrea M. Chambers, Jiao Wang, Kyle B. Lupo, Hao Yu, Nadia M. Atallah Lanman, Sandro Matosevic
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
NK cells
adenosine
immunometabolism
immunotherapy
purinergic signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02533/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02533/full

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