Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis. We test, whether TMAO augments angiotensin II (Ang II)-in...

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Bibliographic Details
Main Authors: Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Trimethylamine N-oxide
Angiotensin II
Blood pressure
Afferent arteriole
Calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002743

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http://www.sciencedirect.com/science/article/pii/S2213231721002743

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