IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs. Here, we find that the insulin receptor substrate (IRS)−...

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Bibliographic Details
Main Authors: Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
IGF
IGF-I receptor
IRS
clathrin
AP2
Online Access:https://elifesciences.org/articles/32893

Internet

https://elifesciences.org/articles/32893

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