Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma

Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma

Anaplastic lymphoma kinase (ALK) translocation is an actionable mutation in lung adenocarcinoma. Nonetheless tumour consists of heterogeneous cell subpopulations with diverse phenotypes and genotypes, and cancer cells can actively release extracellular vesicles (EVs) to modulate the phenotype of oth...

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Bibliographic Details
Main Authors: Hoi-Hin Kwok, Ziyu Ning, Peony Wing-Chi Chong, Thomas Shek-Kong Wan, Margaret Heung-Ling Ng, Gloria Y.F. Ho, Mary Sau-Man Ip, David Chi-Leung Lam
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
extracellular vesicles
TKI-resistance
anaplastic lymphoma kinase
non-small cell lung cancer
intratumoural heterogeneity
Online Access:http://www.mdpi.com/2072-6694/11/1/104

Internet

http://www.mdpi.com/2072-6694/11/1/104

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