The p52 isoform of SHC1 is a key driver of breast cancer initiation

The p52 isoform of SHC1 is a key driver of breast cancer initiation

Abstract Background SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer. Despite the broad evidence implicating SHC1 gene products as a central mediator of...

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Bibliographic Details
Main Authors: Kevin D. Wright, Bradley S. Miller, Sarah El-Meanawy, Shirng-Wern Tsaih, Anjishnu Banerjee, Aron M. Geurts, Yuri Sheinin, Yunguang Sun, Balaraman Kalyanaraman, Hallgeir Rui, Michael J. Flister, Andrey Sorokin
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Breast Cancer Research
Subjects:
DMBA
Shc proteins
Breast cancer
Signaling
Rat model
Online Access:http://link.springer.com/article/10.1186/s13058-019-1155-7

Internet

http://link.springer.com/article/10.1186/s13058-019-1155-7

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