Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics

Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics

To unequivocally address their unresolved intimate structures in blood, we scrutinized the size distribution of circulating cell-free DNA (cfDNA) using whole-genome sequencing (WGS) from both double- and single-strand DNA library preparations (DSP and SSP, n = 7) and using quantitative PCR (Q-PCR, n...

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Bibliographic Details
Main Authors: Cynthia Sanchez, Benoit Roch, Thibault Mazard, Philippe Blache, Zahra Al Amir Dache, Brice Pastor, Ekaterina Pisareva, Rita Tanos, Alain R. Thierry
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Genetics
Oncology
Online Access:https://doi.org/10.1172/jci.insight.144561

Internet

https://doi.org/10.1172/jci.insight.144561

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