Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety and panic-associated circuitry. Recent studies support a role for the orexin system and in particular the orexin 1 receptor (OX1R) in coordina...

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Bibliographic Details
Main Authors: Pascal Bonaventure, Christine Dugovic, Brock Shireman, Cathy Preville, Sujin Yun, Brian Lord, Diane Nepomuceno, Michelle Wennerholm, Timothy Lovenberg, Nicolas Carruthers, Stephanie D. Fitz, Anantha Shekhar, Philip L. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
orexin
hypocretin
panic
anxiety
hypercapnia
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00357/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00357/full

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