Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development

Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development

Abstract Mice lacking secreted IgM (sIgM −/−) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM −/− m...

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Bibliographic Details
Main Authors: Dimitrios Tsiantoulas, Mate Kiss, Barbara Bartolini-Gritti, Andreas Bergthaler, Ziad Mallat, Hassan Jumaa, Christoph J. Binder
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03688-8

Internet

https://doi.org/10.1038/s41598-017-03688-8

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