Family-based exome sequencing identifies RBM45 as a possible candidate gene for frontotemporal dementia and amyotrophic lateral sclerosis

Family-based exome sequencing identifies RBM45 as a possible candidate gene for frontotemporal dementia and amyotrophic lateral sclerosis

Neurodegenerative disorders like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are pathologically characterized by toxic protein deposition in the cytoplasm or nucleus of affected neurons and glial cells. Many of these aggregated proteins belong to the class of RNA binding pr...

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Bibliographic Details
Main Authors: Julie van der Zee, Lubina Dillen, Yalda Baradaran-Heravi, Helena Gossye, Cemile Koçoğlu, Ivy Cuyt, Bart Dermaut, Anne Sieben, Jonathan Baets, Peter De Jonghe, Rik Vandenberghe, Peter De Deyn, Patrick Cras, Sebastiaan Engelborghs, Christine Van Broeckhoven
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Disease
Subjects:
Frontotemporal dementia, FTD
Amyotrophic lateral sclerosis, ALS
Neurodegeneration
RBM45
RNA binding protein
TDP-43 proteinopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001704

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http://www.sciencedirect.com/science/article/pii/S0969996121001704

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