Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer’s disease and cerebrovascular disease pathologies

Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer’s disease and cerebrovascular disease pathologies

Abstract TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology i...

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Bibliographic Details
Main Authors: Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Acta Neuropathologica Communications
Subjects:
FTD
VCID
Arteriosclerosis
Apolipoprotein E
Online Access:http://link.springer.com/article/10.1186/s40478-018-0641-y

Internet

http://link.springer.com/article/10.1186/s40478-018-0641-y

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