Functional expression of human prostaglandin E2 receptor 4 (EP4) in E. coli and characterization of the binding property of EP4 with Gα proteins

Functional expression of human prostaglandin E2 receptor 4 (EP4) in E. coli and characterization of the binding property of EP4 with Gα proteins

Human prostaglandin E2 receptor 4 (EP4) is one of the four subtypes of prostaglandin E2 (PGE2) receptors and belongs to the rhodopsin-type G protein-coupled receptor (GPCR) family. Particularly, EP4 is expressed in various cancer cells and is involved in cancer-cell proliferation by a G protein sign...

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Bibliographic Details
Main Authors: Nam Hyuk Kim, Key-Sun Kim, Sang Chul Shin, Eunice Eunkyeong Kim, Yeon Gyu Yu
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
EP4
GPCR
PGE2
Overexpression
Purification
G protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301813

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http://www.sciencedirect.com/science/article/pii/S2405580820301813

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