Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease

Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests clinical, pathological and genetic overlap between Alzheimer disease, dementia with Lewy bodies...

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Bibliographic Details
Main Authors: Laura Ibanez, Umber Dube, Albert A. Davis, Maria V. Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Sara Ortega-Cubero, Pau Pastor, Joel S. Perlmutter, Carlos Cruchaga, Bruno A. Benitez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson disease
dementia
cognitive impairment
rare variants
APP
PSEN1
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00230/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00230/full

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