Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster

Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster

In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especia...

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Bibliographic Details
Main Authors: Lucyna Walkowicz, Ewelina Kijak, Wojciech Krzeptowski, Jolanta Górska-Andrzejak, Vassilis Stratoulias, Olga Woznicka, Elzbieta Chwastek, Tapio I. Heino, Elzbieta M. Pyza
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Neuroscience
Subjects:
MANF
CDNF
neurotrophic factor
visual system
neuroprotection
neurodegeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00610/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00610/full

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