VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells

VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor (KSHV/vGPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma. We have previously shown that 1α,25(OH)2D3 or its less-calcemic analog TX 527 inhibits the proliferation of endothelial cells expressing vGPCR, NF-...

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Bibliographic Details
Main Authors: Alejandra Suares, Cinthya Tapia, Verónica González-Pardo
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Heliyon
Subjects:
Biochemistry
Molecular biology
Cancer research
Endocrinology
Active vitamin D
Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S240584401936027X

Internet

http://www.sciencedirect.com/science/article/pii/S240584401936027X

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