The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

Abstract Background The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor...

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Bibliographic Details
Main Authors: Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Cell Communication and Signaling
Subjects:
CXCR4
Plerixafor
AMD3100
Receptor tyrosine kinases
PDGFRB
SRC
Online Access:http://link.springer.com/article/10.1186/s12964-018-0233-2

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http://link.springer.com/article/10.1186/s12964-018-0233-2

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