Applying microsatellite multiplex PCR analysis (MMPA) for determining allele copy-number status and percentage of normal cells within tumors.

Applying microsatellite multiplex PCR analysis (MMPA) for determining allele copy-number status and percentage of normal cells within tumors.

The study of somatic genetic alterations in tumors contributes to the understanding and management of cancer. Genetic alterations, such us copy number or copy neutral changes, generate allelic imbalances (AIs) that can be determined using polymorphic markers. Here we report the development of a simp...

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Bibliographic Details
Main Authors: Carles Garcia-Linares, Jaume Mercadé, Bernat Gel, Josep Biayna, Ernest Terribas, Conxi Lázaro, Eduard Serra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3419736?pdf=render

Internet

http://europepmc.org/articles/PMC3419736?pdf=render

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