Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies

Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies

Abstract Ubiquitination-mediated proteolysis or regulation of proteins, ultimately executed by E3 ubiquitin ligases, control a wide array of cellular processes, including transcription, cell cycle, autophagy and apoptotic cell death. HECT-type E3 ubiquitin ligases can be distinguished from other sub...

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Bibliographic Details
Main Authors: Vincenza Simona Delvecchio, Claudia Fierro, Sara Giovannini, Gerry Melino, Francesca Bernassola
Format: Article
Language:English
Published: Springer 2021-10-01
Series:Discover Oncology
Subjects:
Leukemia
Ubiquitin
Ubiquitination
HECT-type E3 ubiquitin protein ligases
Proteasomal degradation
Online Access:https://doi.org/10.1007/s12672-021-00435-4

Internet

https://doi.org/10.1007/s12672-021-00435-4

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