A glycine substitution in the collagenous domain of Col4a3 in mice recapitulates late onset Alport syndrome

A glycine substitution in the collagenous domain of Col4a3 in mice recapitulates late onset Alport syndrome

Alport syndrome (AS) is a severe inherited glomerulopathy caused by mutations in the genes encoding the α-chains of type-IV collagen, the most abundant component of the extracellular glomerular basement membrane (GBM). Currently most AS mouse models are knockout models for one of the collagen-IV gen...

Full description

Bibliographic Details
Main Authors: Christoforos Odiatis, Isavella Savva, Myrtani Pieri, Pavlos Ioannou, Petros Petrou, Gregory Papagregoriou, Kyriaki Antoniadou, Neoklis Makrides, Charalambos Stefanou, Danica Galešić Ljubanović, Georgios Nikolaou, Dorin-Bogdan Borza, Kostas Stylianou, Oliver Gross, Constantinos Deltas
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Matrix Biology Plus
Subjects:
Collagen-IV
Glomerular basement membrane
Alport syndrome
Glycine missense mutation
Kidney disease
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S259002852030034X

Internet

http://www.sciencedirect.com/science/article/pii/S259002852030034X

Similar Items