BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis.
The double bromodomain and extra-terminal domain (BET) proteins are critical epigenetic readers that bind to acetylated histones in chromatin and regulate transcriptional activity and modulate changes in chromatin structure and organization. The testis-specific BET member, BRDT, is essential for the...
Main Authors: | Marcia Manterola, Taylor M Brown, Min Young Oh, Corey Garyn, Bryan J Gonzalez, Debra J Wolgemuth |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-03-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5841650?pdf=render |
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