Preclinical Detection of Prions in Blood of Nonhuman Primates Infected with Variant Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob disease (vCJD) is caused by prion infection with bovine spongiform encephalopathy and can be transmitted by blood transfusion. Protein misfolding cyclic amplification (PMCA) can detect prions in blood from vCJD patients with 100% sensitivity and specificity. To determine wh...

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Bibliographic Details
Main Authors: Luis Concha-Marambio, Marcelo A. Chacon, Claudio Soto
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2020-01-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/26/1/18-1423_article