Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues.

Sensorineural hearing loss is one of the most common disabilities worldwide. Such prevalence necessitates effective tools for studying the molecular workings of cochlear cells. One prominent and effective vector for expressing genes of interest in research models is adeno-associated virus (AAV). How...

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Bibliographic Details
Main Authors: Graham Casey, Charles Askew, Mark A Brimble, R Jude Samulski, Andrew M Davidoff, Chengwen Li, Bradley J Walters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0242599